Signals vs Noise Article







November 2003 Stock Report

Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
GENOME THERAPEUTICS CORP $2.95 74% 56% $93 $27 $66 $15 152 $0.4 -$55.6 0.5 3.3
HUMAN GENOME SCIENCES $12.59 71% 18% $1,627 $1,152 $475 $503 1086 $0.4 -$189.2 6.1 0.9
INCYTE CORP $6.17 95% 15% $447 $349 $98 $172 585 $0.2 -$107.2 3.3 0.6
MILLENNIUM PHARMACEUTICALS $15.63 85% 56% $4,709 $1,545 $3,164 $83 2079 $1.5 -$428.0 3.6 1.1
MYRIAD GENETICS $11.60 60% -39% $314 $86 $228 $0 491 $0.5 -$28.4 3.0 1.2
1st Generation Genomics Average   77% 21% $1,438 $632 $806 $155   $0.6 -$161.7 3.3 1.4
1st Generation Genomics Median   74% 18% $447 $349 $228 $83   $0.4 -$107.2 3.3 1.1
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ACLARA BIOSCIENCES $3.23 69% 37% $116 $79 $37 $0 95 $0.4 -$20.4 3.9 0.4
AFFYMETRIX $24.92 83% -8% $1,479 $434 $1,045 $369 877 $1.2 na na 4.1
CALIPER TECHNOLOGIES $6.30 88% 80% $178 $134 $43 $1 251 $0.2 -$38.2 3.5 0.7
CEPHEID $7.35 95% 20% $264 $11 $253 $0 148 $1.7 -$17.7 0.6 3.0
CIPHERGEN BIOSYSTEMS $10.20 73% 192% $294 $21 $274 $30 323 $0.8 -$62.4 0.3 1.7
COMBIMATRIX $4.00 79% na $105 $43 $62 $0 14 na -$26.7 na na
COMPUGEN $5.08 81% 239% $133 na na $0 176 na -$12.8 na na
ILLUMINA $6.75 93% 35% $222 $55 $167 $25 233 $0.7 -$22.0 2.5 3.5
NANOGEN $3.27 66% 60% $80 $30 $50 $0 195 $0.3 -$27.6 1.1 0.4
ORCHID BIOSCIENCES $1.27 64% 102% $96 $4 na $2 492 na -$40.8 na 0.3
SEQUENOM $3.56 85% 63% $142 $75 $67 $10 216 $0.3 -$37.4 2.0 0.3
TRANSGENOMIC $1.81 43% -40% $46 $3 $43 $1 326 $0.1 -$14.4 0.2 0.4
Genomic Supply Average   76% 71% $263 $81 $204 $37   $0.6 -$29.1 1.8 1.5
Genomic Supply Median   80% 60% $138 $43 $65 $1   $0.4 -$26.7 1.5 0.6
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
APPLIED MOLECULAR EVOLUTION $17.70 98% 781% $371 $53 $319 $10 106 $3.0 -$22.8 2.3 2.3
ARENA PHARMACEUTICALS $6.60 77% -1% $169 $163 $6 $0 336 $0.0 -$46.8 3.5 0.6
CELERA GENOMICS GROUP $13.61 94% 21% $988 na na $0 na na na na na
CURAGEN CORP $6.26 89% 17% $311 $372 -$61 $150 857 -$0.1 -$93.7 4.0 0.6
DECODE GENETICS $8.21 84% 222% $443 $69 $374 $46 530 $0.7 -$40.0 1.7 1.0
EXELIXIS $6.48 66% -28% $461 $260 $200 $60 550 $0.4 -$93.6 2.8 1.0
GENAISSANCE PHARMACEUTICALS $2.92 87% 192% $67 $26 $41 $0 104 $0.4 -$15.2 1.7 0.3
GENE LOGIC $5.00 58% -36% $156 $153 $2 $1 264 $0.0 -$15.6 9.8 0.4
GENENCOR INTERNATIONAL $16.25 93% 44% $962 $144 $818 $57 1098 $0.7 na na 1.8
LARGE SCALE BIOLOGY $1.75 60% 51% $45 $11 $34 $0 114 $0.3 -$30.5 0.4 0.2
LEXICON GENETICS $5.49 74% 37% $345 $142 $202 $4 579 $0.3 -$68.6 2.1 1.0
LYNX THERAPEUTICS $4.85 57% -12% $26 $5 $22 $1 128 $0.2 -$11.2 0.4 0.2
MAXYGEN $10.74 69% 33% $374 $192 $182 $0 280 $0.7 -$22.4 8.6 1.0
NUVELO $3.69 92% 265% $281 $25 $256 $5 98 $2.6 -$64.0 0.4 1.4
PARADIGM GENETICS $1.20 62% 118% $39 $7 $32 $2 194 $0.2 -$14.4 0.5 0.4
RIGEL PHARMACEUTICALS $16.30 98% 34% $241 $12 $229 $0 160 $1.4 -$42.0 0.3 1.7
SANGAMO BIOSCIENCES $4.70 83% -5% $117 $46 $71 $0 74 $1.0 -$13.2 3.5 0.9
ZYMOGENETICS $13.45 75% 74% $705 $329 $376 $0 364 $1.0 -$52.5 6.3 1.7
Genomic Targets Average   79% 100% $339 $118 $182 $19   $0.8 -$40.4 3.0 1.0
Genomic Targets Median   80% 36% $296 $69 $182 $1   $0.4 -$35.3 2.2 1.0
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
EDEN BIOSCIENCES $1.60 71% -4% $39 $23 $16 $0 55 $0.3 -$13.2 1.7 0.3
EMBREX $12.55 93% 7% $103 $10 $93 $0 241 $0.4 na na 1.7
IDEXX LABORATORIES $47.28 96% 51% $1,648 $192 $1,456 $0 1281 $1.1 na na 4.7
IMMUCELL CORP $3.00 62% 30% $8 $4 $4 $0 26 $0.1 na na 0.9
NEOGEN $21.25 97% 65% $133 $8 $125 $0 265 $0.5 na na 5.3
Agbio/enviro. Average   84% 30% $386 $47 $339 $0   $0.5 -$13.2 1.7 2.6
Agbio/enviro. Median   93% 30% $103 $10 $93 $0   $0.4 -$13.2 1.7 1.7
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ALEXION PHARMACEUTICALS $18.62 86% 6% $339 $279 $60 $124 172 $0.4 -$85.9 3.2 0.9
ATHEROGENICS $14.30 76% 104% $525 $61 $464 $100 85 $5.5 -$49.2 1.2 3.1
AUTOIMMUNE $1.68 75% 82% $28 $11 $17 $0 2 $8.7 -$0.6 19.4 0.2
CONNETICS CORP $17.97 93% 50% $572 $27 $545 $80 190 $2.9 -$7.2 3.8 3.3
CORTECH $2.75 84% 12% $10 $0 $10 $0 na na -$0.3 -0.2 na
CYPRESS BIOSCIENCE $13.50 95% 614% $299 $3 $296 $0 10 $29.6 -$30.0 0.1 2.6
ICOS CORP $44.41 93% 40% $2,793 $117 $2,677 $250 525 $5.1 -$156.0 0.7 3.6
INKINE PHARMACEUTICAL CO $5.64 95% 130% $273 $12 $261 $12 49 $5.3 na na 4.3
LA JOLLA PHARMACEUTICAL CO $2.92 33% -58% $149 $51 $98 $1 156 $0.6 -$39.7 1.3 0.7
PROTEIN DESIGN LABS $13.67 66% 50% $1,281 $587 $694 $400 397 $1.7 -$20.0 29.4 2.0
TANOX $14.94 66% 35% $656 $216 $439 $5 127 $3.5 na na 2.1
Autoimmune Average   78% 97% $630 $124 $506 $88   $6.3 -$43.2 6.6 2.3
Autoimmune Median   84% 50% $339 $51 $296 $12   $4.3 -$30.0 1.3 2.3
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ALLOS THERAPEUTICS $2.70 33% -66% $70 $37 $33 $0 92 $0.4 -$46.8 0.8 0.4
ANTIGENICS $11.76 74% -4% $464 $86 $378 $0 212 $1.8 -$66.4 1.3 1.3
APHTON CORP $6.51 65% 143% $187 $2 $185 $3 56 $3.3 -$32.6 na 1.4
ARIAD PHARMACEUTICALS $7.95 96% 185% $362 $17 $345 $6 52 $6.6 -$17.6 1.0 2.3
AVI BIOPHARMA $4.78 64% -18% $149 $8 $141 $0 89 $1.6 -$14.0 0.6 1.1
BIOMIRA $1.56 32% 36% $113 $78 $35 $0 115 $0.3 -$17.8 4.4 1.3
BOSTON LIFE SCIENCES $1.58 53% 2% $51 $11 $40 $0 14 $2.9 -$7.6 1.5 na
CELGENE CORP $45.33 93% 84% $3,683 $258 $3,425 $400 560 $6.1 na na 6.2
CELL THERAPEUTICS $9.00 57% -6% $306 $79 $227 $190 286 $0.8 -$122.8 0.6 0.8
CORIXA CORP $5.90 60% -19% $326 $41 $285 $106 366 $0.8 -$83.6 0.5 0.3
CYTOGEN CORP $10.95 74% 96% $141 $9 $132 $0 49 $2.7 -$7.8 1.2 0.4
DENDREON $7.45 71% 83% $333 $39 $294 $0 117 $2.5 -$33.2 1.2 2.1
DUSA PHARMACEUTICALS $5.24 76% 183% $73 $44 $29 $1 43 $0.7 -$15.2 2.9 0.8
ENTREMED $3.91 60% 170% $144 $1 $143 $0 58 $2.5 -$22.0 0.0 0.6
EXEGENICS $0.55 61% 19% $9 na na $0 8 na -$7.2 na 0.1
GENAERA $3.83 58% 715% $172 $6 $166 $0 22 $7.5 -$6.1 1.0 0.9
GENTA $10.15 58% -10% $770 $100 $669 $28 96 $7.0 -$12.6 8.0 2.4
GERON CORP $11.89 71% 205% $465 $99 $366 $16 92 $4.0 -$36.8 2.7 1.8
ILEX ONCOLOGY $20.98 94% 92% $818 $246 $572 $37 277 $2.1 -$35.2 7.0 1.8
IMCLONE SYSTEMS $38.59 79% 181% $2,893 $259 $2,634 $242 399 $6.6 -$138.0 1.9 8.4
IMMUNOGEN $4.75 79% 21% $193 $508 -$316 $0 1618 -$0.2 -$27.6 18.4 0.1
IMMUNOMEDICS $3.77 39% -49% $188 $25 $163 $0 94 $1.7 -$14.8 1.7 1.2
MAXIM PHARMACEUTICALS $7.25 95% 104% $170 $76 $93 $1 115 $0.8 -$49.6 1.5 0.5
MEDAREX $6.59 86% 29% $519 $292 $227 $175 431 $0.5 -$116.5 2.5 0.8
NAPRO BIOTHERAPEUTICS $1.79 56% 6% $55 $4 $51 $25 151 $0.3 -$8.5 0.5 0.5
NEOPHARM $17.93 96% 22% $338 $64 $273 $0 100 $2.7 -$65.6 1.0 2.0
NEORX CORP $4.10 57% 494% $115 $17 $97 $5 36 $2.7 na na 0.5
OSI PHARMACEUTICALS $28.65 75% 33% $1,037 $279 $758 $295 429 $1.8 -$300.0 0.9 1.5
OXIGENE $9.84 51% 556% $138 $9 $130 $0 10 $13.0 -$5.9 1.4 1.7
PRAECIS PHARMACEUTICALS $7.65 97% 137% $397 $166 $231 $33 110 $2.1 -$62.0 2.7 1.1
PROGENICS PHARMACEUTICALS $17.15 82% 129% $227 $77 $150 $0 100 $1.5 -$31.2 2.5 2.5
QLT INC $16.47 90% 66% $1,134 $137 $997 $172 336 $3.0 na na 2.9
SCICLONE PHARMACEUTICALS $7.23 74% 82% $321 $66 $255 $6 97 $2.6 -$11.4 5.8 2.0
SEATTLE GENETICS $6.39 91% 97% $198 $16 $182 $0 97 $1.9 -$22.0 0.7 1.9
SPECTRUM PHARMACEUTICALS $5.85 56% 184% $38 $3 $35 $0 18 $2.0 -$6.6 0.4 0.3
SUPERGEN $10.45 93% 127% $371 $19 $352 $8 107 $3.3 -$50.0 0.4 1.3
VERNALIS $2.52 70% -3% $43 $269 -$227 $5 96 -$2.4 -$59.4 4.5 0.1
XENOVA GROUP PLC $1.96 27% -61% $34 $29 $5 $0 134 $0.0 -$23.6 1.2 1.2
Cancer Average   70% 106% $449 $94 $366 $46   $2.6 -$45.1 2.5 1.5
Cancer Median   71% 83% $195 $44 $182 $1   $2.1 -$27.6 1.3 1.2
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
CV THERAPEUTICS $17.41 42% -25% $506 $378 $127 $196 205 $0.6 -$91.4 4.1 0.9
ENCYSIVE PHARMACEUTICALS $7.50 96% 283% $335 $34 $301 $0 104 $2.9 -$56.8 0.6 1.6
MEDICINES COMPANY $27.46 87% 64% $1,300 $136 $1,164 $0 147 $7.9 -$26.3 5.2 2.9
QUESTCOR PHARMACEUTICALS $0.69 51% -31% $31 $13 $18 $3 52 $0.3 -$8.4 1.5 0.3
Cardiovascular Average   69% 73% $543 $140 $402 $50   $2.9 -$45.7 2.9 1.4
Cardiovascular Median   69% 19% $420 $85 $214 $2   $1.8 -$41.6 2.8 1.2
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ALBANY MOLECULAR RESEARCH $13.92 77% -7% $440 $132 $308 $66 860 $0.4 na na 2.4
ARGONAUT TECHNOLOGIES $1.29 74% 43% $26 $22 $5 $12 215 $0.0 -$7.6 2.8 0.2
ARQULE $5.04 78% -15% $142 $84 $58 $5 298 $0.2 na na 0.6
ARRAY BIOPHARMA $4.96 58% -41% $141 $35 $106 $0 245 $0.4 -$23.6 1.5 1.1
BIOCRYST PHARMACEUTICALS $8.24 88% 670% $146 $20 $126 $0 44 $2.9 -$13.0 1.5 1.1
DISCOVERY PARTNERS $5.87 87% 85% $145 $69 $76 $0 236 $0.3 -$5.2 13.3 0.7
KOSAN BIOSCIENCES $9.60 97% 46% $246 $53 $193 $0 112 $1.7 -$2.1 25.5 1.7
PHARMACOPEIA $12.28 76% 23% $293 $143 $150 $0 687 $0.2 -$14.8 9.6 1.0
SYMYX TECHNOLOGIES $19.95 78% 66% $628 $128 $501 $0 213 $2.4 na na 4.1
VERTEX PHARMACEUTICALS $8.80 46% -53% $684 $639 $45 $315 980 $0.0 -$164.0 3.9 0.9
Chemistry Average   76% 82% $289 $132 $157 $40   $0.9 -$32.9 8.3 1.4
Chemistry Median   77% 33% $196 $77 $116 $0   $0.3 -$13.0 3.9 1.1
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ADOLOR $19.70 98% 36% $624 $241 $383 $0 124 $3.1 -$55.2 4.4 2.4
CEPHALON $46.83 83% -14% $2,606 $565 $2,041 $1,610 1271 $1.6 na na 2.5
DOV PHARMACEUTICALS $10.85 58% 67% $178 $53 $126 $14 32 $3.9 -$18.8 2.8 2.2
GUILFORD PHARMACEUTICALS $6.78 83% 36% $197 $61 $136 $64 235 $0.6 -$22.1 2.7 0.6
INDEVUS PHARMACEUTICALS $5.66 82% 152% $266 $21 $245 $72 24 $10.2 -$48.2 0.4 0.9
NEUROBIOLOGICAL TECHNOLOGIES $4.25 48% -32% $82 $4 $78 $0 11 $7.1 -$2.8 1.4 1.8
NEUROCRINE BIOSCIENCES $53.24 88% 16% $1,878 $496 $1,382 $0 276 $5.0 -$41.2 12.0 4.4
NYMOX PHARMACEUTICAL $2.66 59% -33% $64 na na $0 228 na -$4.5 na na
PAIN THERAPEUTICS $6.07 68% 67% $215 $95 $120 $0 30 $4.0 -$23.9 4.0 2.1
PHARMOS CORP $3.70 74% 187% $274 $12 $261 $42 67 $3.9 -$17.2 0.7 2.3
STEMCELLS $2.15 69% 169% $73 $2 $71 $0 28 $2.5 -$10.4 0.2 0.5
TITAN PHARMACEUTICALS $2.79 70% 5% $81 $59 $21 $0 72 $0.3 -$26.7 2.2 0.4
CNS Average   73% 55% $545 $146 $442 $150   $3.8 -$24.6 3.1 1.8
CNS Median   72% 36% $206 $59 $136 $0   $3.9 -$22.1 2.5 2.1
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
BIOSOURCE INTERNATIONAL $7.08 89% 21% $66 $4 $62 $0 296 $0.2 na na 1.5
GTC BIOTHERAPEUTICS $2.85 66% 142% $91 $42 $49 $13 182 $0.3 -$24.0 1.7 0.5
HARVARD BIOSCIENCE $7.35 83% 115% $221 $10 $211 $0 386 $0.5 na na 1.3
ICON PLC $42.00 93% 80% $497 $54 na $0 1637 na na na na
INVITROGEN CORP $67.89 99% 143% $3,686 $781 $2,905 $697 2744 $1.1 na na 2.0
MOLECULAR DEVICES CORP $20.02 96% 5% $297 $58 $239 $0 433 $0.6 na na 1.6
NEOSE TECHNOLOGIES $8.70 62% -37% $173 $42 $132 $8 124 $1.1 -$39.7 1.1 0.9
PARAXEL INTERNATIONAL $18.29 98% 47% $474 $79 $395 $1 4930 $0.1 na na 2.8
PHARMACEUTICAL PRODUCT DEVELOP $29.72 92% -1% $1,664 $203 $1,461 $6 5300 $0.3 na na 6.1
QIAGEN NV $11.22 85% 73% $1,634 $41 $1,593 $0 1651 $1.0 na na 32.9
CRO/Service/Supply Average   86% 59% $880 $131 $783 $73   $0.6 -$31.8 1.4 5.5
CRO/Service/Supply Median   90% 60% $386 $48 $239 $0   $0.5 -$31.8 1.4 1.6
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ABGENIX $11.52 68% 24% $1,016 $280 $737 $200 387 $1.9 -$264.4 1.1 1.1
AEROGEN $1.81 28% -36% $37 $1 $36 $0 80 $0.5 -$14.6 0.1 0.3
ALKERMES $12.86 79% 44% $1,150 $128 $1,022 $385 520 $2.0 -$120.0 1.1 2.4
ANDRX $21.95 85% 51% $1,581 $81 $1,500 $0 2100 $0.7 na na 3.2
ARADIGM CORP $1.77 50% -7% $97 $29 $68 $0 285 $0.2 -$29.6 1.0 0.4
ATRIX LABORATORIES $20.52 66% 12% $440 $95 $345 $0 167 $2.1 -$2.9 33.0 1.7
BIODELIVERY SCIENCES $2.12 42% -18% $15 $5 $10 $0 19 $0.5 -$1.2 4.4 1.1
CIMA LABS $33.00 99% 24% $479 $75 $404 $0 219 $1.8 na na 2.0
DEPOMED $6.70 79% 274% $226 $46 $180 $0 51 $3.5 -$28.8 1.6 3.3
DOR  BIOPHARMA $0.74 43% 85% $26 $2 $23 $0 5 $4.7 -$3.2 0.7 0.3
DURECT $2.22 50% -17% $114 $32 $81 $50 6 $13.6 -$20.5 1.6 0.6
EMISPHERE TECHNOLOGIES $5.99 65% 51% $109 $41 $67 $34 124 $0.5 -$45.8 0.9 0.3
ENZON PHARMACEUTICALS $10.79 56% -42% $470 $140 $330 $0 127 $2.6 na na 1.8
FLAMEL TECHNOLOGIES SA $28.89 66% 614% $472 $77 $395 $2 150 $2.6 -$8.9 8.7 9.2
GENEREX BIOTECHNOLOGY $1.62 55% -23% $45 $8 $36 $2 23 $1.6 -$12.6 0.7 0.5
GENETRONICS BIOMEDICAL LTD $1.02 70% 264% $60 $1 $59 $0 26 $2.3 -$5.6 0.1 1.0
KOS PHARMACEUTICALS $44.18 93% 114% $972 $203 $769 $0 726 $1.1 na na 4.4
MACROCHEM CORP $1.15 70% 102% $38 $7 $31 $0 13 $2.4 -$2.2 3.2 0.5
MEDICIS PHARMACEUTICAL $65.79 95% 42% $1,804 $552 $1,252 $400 279 $4.5 na na 4.1
NASTECH PHARMACEUTICAL $10.20 85% 1% $121 $14 $107 $4 63 $1.7 -$11.7 1.2 1.9
NEKTAR THERAPEUTICS $13.20 86% 45% $741 $239 $502 $399 680 $0.7 -$52.0 4.6 1.0
NOVAVAX $5.60 65% 48% $169 $9 $160 $41 121 $1.3 -$20.0 0.5 1.4
NOVEN PHARMACEUTICALS $13.86 93% 31% $312 $68 $244 $0 274 $0.9 na na 4.0
SEPRACOR $24.40 74% 155% $2,071 $448 $1,623 $983 818 $2.0 -$135.2 3.3 2.6
Delivery Average   69% 77% $523 $108 $416 $104   $2.3 -$43.3 3.8 2.1
Delivery Median   69% 43% $269 $57 $212 $0   $1.9 -$17.3 1.1 1.6
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ADVANCED MAGNETICS $14.10 93% 185% $109 $16 $93 $0 23 $4.1 na na 2.5
BIOSITE $26.57 46% -7% $414 $79 $335 $7 513 $0.7 na na 5.1
CHOLESTECH CORP $7.71 60% 17% $108 $17 $91 $0 220 $0.4 na na 1.3
DIAGNOSTIC PRODUCTS CORP $44.97 99% 24% $1,296 $49 $1,247 $0 2100 $0.6 na na 21.1
DIGENE CORP $39.39 80% 385% $738 $31 $707 $3 243 $2.9 na na 6.4
ENZO BIOCHEM $18.22 64% 26% $547 $77 $470 $0 231 $2.0 -$10.1 7.6 3.4
EPIX MEDICAL $17.75 86% 92% $391 $18 $373 $0 93 $4.0 -$13.6 1.3 3.3
EXACT SCIENCES $10.00 56% -18% $192 $27 $165 $0 75 $2.2 -$31.5 0.9 1.6
GEN-PROBE $33.75 97% 198% $1,640 $8 na $0 186 na na na na
HYCOR BIOMEDICAL $4.20 65% 95% $34 $5 $29 $0 148 $0.2 na na 2.6
IGEN INTERNATIONAL $58.94 98% 56% $1,472 $34 $1,437 $45 370 $3.9 -$28.8 1.2 6.1
IMMUCOR $22.85 98% -1% $446 $9 $437 $20 481 $0.9 na na 14.7
LUMINEX $10.50 97% 112% $317 $38 $280 $0 117 $2.4 -$7.6 4.9 2.6
MARTEK BIOSCIENCES CORP $59.90 99% 159% $1,650 $196 $1,454 $0 198 $7.3 na na 5.1
MATRITECH $2.02 67% 3% $72 $5 $67 $4 50 $1.3 -$7.2 0.7 0.9
MERIDIAN BIOSCIENCE $10.32 90% 54% $152 $5 $147 $23 350 $0.4 na na 6.4
ORASURE $8.40 77% 40% $369 $63 $306 $3 187 $1.6 na na 2.4
QUIDEL CORP $8.46 91% 173% $247 $13 $234 $10 330 $0.7 -$1.5 8.9 1.8
SONUS PHARMACEUTICALS $4.94 77% 76% $89 $11 $78 $0 37 $2.1 -$12.4 0.9 1.6
TRINITY BIOTECH PLC $3.49 79% 168% $150 $1 $148 $0 332 $0.4 na na 6.9
Diagnostic/imag. Average   81% 92% $522 $35 $426 $6   $2.0 -$14.1 3.3 5.0
Diagnostic/imag. Median   83% 66% $343 $17 $280 $0   $1.6 -$11.2 1.2 3.3
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
AASTROM BIOSCIENCES $1.43 78% 147% $102 $7 $94 $0 44 $2.1 -$11.2 0.7 0.9
AVIGEN $6.51 63% -18% $132 $98 $33 $8 102 $0.3 -$24.2 4.1 0.6
CELL GENESYS $12.70 83% -3% $504 $142 $362 $60 336 $1.1 -$76.0 1.9 1.7
CORAUTUS GENETICS $5.86 90% 139% $59 $0 $59 $0 17 $3.5 -$11.6 0.0 0.9
GENVEC $3.51 78% -5% $179 $6 $173 $6 95 $1.8 -$24.0 0.2 1.6
INTROGEN $6.99 62% 197% $165 $15 $150 $7 50 $3.0 -$16.2 0.9 1.8
SIRNA THERAPEUTICS $5.90 52% 89% $187 $37 $149 $4 81 $1.8 -$31.2 1.2 0.9
TARGETED GENETICS CORP $2.09 47% 267% $138 $12 $126 $0 125 $1.0 -$3.1 3.9 0.6
TRANSGENE SA $2.61 56% 37% $79 $0 $79 $0 318 $0.2 -$20.4 0.0 na
TRANSKARYOTIC THERAPIES $12.99 88% 37% $454 $191 $263 $0 345 $0.8 -$84.0 2.3 0.7
VALENTIS $2.50 29% -65% $14 $4 $11 $0 58 $0.2 -$8.2 0.5 0.1
VICAL $5.00 64% 30% $100 $95 $6 $0 165 $0.0 -$27.6 3.4 0.5
Gene therapy Average   66% 71% $176 $51 $125 $7   $1.3 -$28.1 1.6 0.9
Gene therapy Median   64% 37% $135 $14 $110 $0   $1.0 -$22.2 1.1 0.9
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
AVANT IMMUNOTHERAPEUTICS $2.70 78% 82% $175 $17 $158 $0 66 $2.4 -$12.8 1.3 0.8
CUBIST PHARMACEUTICALS $12.44 84% 5% $497 $89 $408 $208 204 $2.0 -$100.0 0.9 2.0
EPIMMUNE $1.81 42% 51% $24 $6 $19 $0 52 $0.4 -$8.1 0.7 0.1
GENELABS TECHNOLOGIES $1.76 84% -6% $152 $28 $123 $0 94 $1.3 -$16.8 1.7 0.8
IMMUNE RESPONSE CORP $1.83 46% 38% $75 na na $5 43 na -$37.2 na 0.3
INTERMUNE $21.27 67% -30% $677 $257 $420 $150 250 $1.7 -$81.2 3.2 1.4
INTRABIOTICS $13.62 87% 266% $72 $8 $64 $0 8 $8.0 -$15.2 0.5 0.3
MEDIMMUNE $23.31 55% -12% $5,770 $581 $5,190 $717 1505 $3.4 na na 2.2
NABI BIOPHARMACEUTICALS $10.91 89% 50% $515 $47 $468 $0 722 $0.6 na na 3.1
SIGA TECHNOLOGIES $1.80 61% 59% $34 $0 $33 $0 17 $2.0 -$4.8 0.1 1.0
TRIMERIS $22.65 41% -53% $488 $122 $366 $0 129 $2.8 -$72.0 1.7 1.2
VAXGEN $8.15 37% -58% $170 $3 $167 $0 117 $1.4 -$30.1 0.1 1.1
VICURON $18.07 95% 60% $973 $203 $771 $0 28 $27.5 -$103.2 2.0 2.2
VION PHARMACEUTICALS $1.64 55% 156% $64 $5 $59 $0 34 $1.7 -$12.5 0.4 0.6
VIROLOGIC $2.67 92% 76% $118 $7 $111 $0 170 $0.7 -$10.8 0.7 1.0
VIROPHARMA $2.80 59% 76% $73 $137 -$64 $130 139 -$0.5 -$28.9 4.7 0.3
XOMA LTD $6.89 64% 24% $573 $99 $474 $71 229 $2.1 -$64.0 1.5 1.1
Infection Average   67% 46% $615 $100 $548 $75   $3.6 -$39.8 1.4 1.1
Infection Median   64% 50% $170 $38 $163 $0   $1.8 -$28.9 1.1 1.0
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
AMYLIN PHARMACEUTICALS $25.44 83% 47% $2,378 $418 $1,960 $175 350 $5.6 -$148.0 2.8 3.4
BIOMARIN PHARMACEUTICAL $7.25 53% -14% $463 $155 $308 $125 219 $1.4 -$39.6 3.9 1.1
INSMED INC $2.91 78% 355% $112 $19 $93 $0 23 $4.0 -$13.0 1.4 na
KERYX BIOPHARMACEUTICALS $4.45 77% 153% $95 $21 $75 $0 24 $3.1 -$6.0 3.4 1.3
NPS PHARMACEUTICALS $30.10 90% 2% $1,111 $145 $966 $170 183 $5.3 -$256.0 0.6 2.3
SAVIENT PHARMACEUTICALS $4.94 73% 17% $292 $26 $266 $11 490 $0.5 na na 1.4
VIVUS $3.61 61% -19% $136 $20 $116 $0 119 $1.0 -$11.7 1.7 1.0
ZONAGEN $1.88 95% 71% $22 $24 -$2 $0 4 -$0.6 -$2.7 8.8 0.2
Metabolic Average   76% 76% $576 $103 $473 $60   $2.5 -$68.1 3.2 1.5
Metabolic Median   78% 47% $136 $24 $116 $1   $1.4 -$12.3 2.3 1.2
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
BIOPURE CORP $3.05 34% -35% $135 $4 $132 $10 249 $0.5 -$45.2 0.1 0.3
BIORELIANCE CORP $46.30 98% 82% $388 $39 $349 $10 638 $0.5 na na 6.9
BIOTIME $1.63 55% -4% $22 $0 $22 $2 12 $1.9 -$3.0 0.0 0.7
CERUS $3.52 14% -86% $78 $134 -$56 $51 158 -$0.4 -$66.8 2.0 2.0
COLLAGENEX PHARMACEUTICALS $10.39 62% 11% $144 $11 $132 $0 148 $0.9 na na 1.7
COLUMBIA LABORATORIES $5.12 32% 31% $203 $2 $201 $10 25 $8.0 -$18.0 0.1 1.6
CURIS $5.13 87% 366% $207 $31 $175 $7 64 $2.7 -$20.2 1.6 0.3
CYANOTECH CORP $1.00 74% 113% $18 $0 $18 $4 58 $0.3 -$0.6 0.9 0.7
CYTRX CORP $2.22 59% 640% $75 $1 $74 $0 3 $24.7 -$20.2 0.0 0.9
DISCOVERY LABORATORIES $8.06 94% 193% $341 $9 $332 $0 65 $5.1 -$19.2 0.5 3.9
INSITE VISION $0.38 38% -49% $10 $0 $10 $0 41 $0.2 -$7.6 0.0 0.1
INSPIRE PHARMACEUTICALS $17.62 82% 112% $561 $99 $462 $0 54 $8.6 -$26.4 3.8 2.8
INTEGRA LIFESCIENCES $31.92 91% 82% $867 $135 $732 $105 760 $1.0 na na 2.9
NORTHFIELD LABORATORIES $5.80 58% 41% $94 $9 $84 $0 60 $1.4 -$11.6 0.8 0.8
OSTEOTECH $7.75 48% 36% $133 $17 $115 $15 338 $0.3 na na 2.1
PALATIN TECHNOLOGIES $2.99 51% 47% $134 $19 $114 $0 46 $2.5 -$25.6 0.7 1.2
PHARMACYCLICS $6.40 96% 83% $104 $87 $17 $0 133 $0.1 -$30.1 2.9 0.4
REPLIGEN CORP $4.80 57% 60% $143 $15 $128 $0 39 $3.3 -$8.1 1.9 0.8
SALIX PHARMACEUTICALS $19.10 89% 105% $419 $33 $386 $0 135 $2.9 -$28.0 1.2 3.2
TRIPOS $7.05 72% -21% $63 $11 $53 $4 337 $0.2 na na 1.8
Other Average   64% 90% $207 $33 $174 $11   $3.2 -$22.0 1.1 1.8
Other Median   62% 60% $134 $11 $115 $1   $1.0 -$19.7 0.8 1.2
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
AMGEN $58.14 80% 23% $75,001 $5,369 $69,632 $3,056 10100 $6.9 na na 3.8
BIOGEN IDEC $38.57 76% 17% $5,766 $2,394 $3,372 $908 3628 $0.9 na na 3.2
CHIRON CORP $53.81 94% 34% $10,101 $905 $9,197 $564 4044 $2.3 na na 4.1
GENENTECH $83.78 95% 154% $43,834 $1,217 $42,616 $0 5252 $8.1 na na 6.6
GENZYME CORP $45.84 87% 40% $10,275 $546 $9,728 $600 5600 $1.7 na na 3.7
GILEAD SCIENCES $58.75 83% 49% $11,897 $712 $11,185 $595 1250 $8.9 na na 11.7
Revenue-driven Average   86% 53% $26,146 $1,857 $24,288 $954   $4.8 na na 5.5
Revenue-driven Median   85% 37% $11,086 $1,061 $10,457 $598   $4.6 na na 4.0
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
DIVERSA $8.19 68% -29% $352 $142 $210 $11 279 $0.8 -$50.4 2.8 1.0
DYAX $6.15 82% 203% $152 $25 $127 $18 244 $0.5 -$24.4 1.0 1.0
ISIS PHARMACEUTICALS $5.89 66% -32% $327 $246 $81 $200 523 $0.2 -$93.2 2.6 0.5
LIGAND PHARMACEUTICALS $13.27 80% 156% $970 $22 $948 $159 402 $2.4 -$48.0 0.5 1.4
NEUROGEN CORP $6.23 81% 8% $112 $63 $48 $14 163 $0.3 -$31.2 2.0 0.6
ONYX PHARMACEUTICALS $27.24 94% 296% $801 $102 $698 $0 89 $7.8 -$45.6 2.2 4.0
REGENERON PHARMACEUTICALS $13.00 58% -40% $719 $283 $436 $200 266 $1.6 -$114.8 2.5 1.2
TULARIK $14.70 97% 53% $873 $237 $635 $0 430 $1.5 -$103.6 2.3 2.1
Screening Average   78% 77% $538 $140 $398 $75   $1.9 -$63.9 2.0 1.5
Screening Median   80% 31% $536 $122 $323 $16   $1.1 -$49.2 2.3 1.1
                         
Company Close 11/26/03 % 52wk High % change from 11/29/02 Market Cap ($M) Pro forma cash ($M) Tech Value ($M) LT Debt plus Convert # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
CARRINGTON LABORATORIES $4.30 67% 310% $44 $2 $42 $2 252 $0.2 -$1.2 1.7 0.8
CELLEGY PHARMACEUTICALS $2.95 48% -21% $59 $7 $52 $0 23 $2.3 -$18.3 0.4 0.6
CURATIVE HEALTH SERVICES $13.08 66% -15% $166 $5 $161 $24 340 $0.5 na na 1.6
LIFECELL CORP $5.44 74% 69% $138 $6 $132 $1 155 $0.9 na na 1.8
LIFECORE BIOMEDICAL $6.60 71% -20% $85 $3 $82 $6 199 $0.4 -$2.3 1.2 1.7
Wound Average   65% 64% $99 $5 $94 $7   $0.8 -$7.3 1.1 1.3
Wound Median   67% -15% $85 $5 $82 $2   $0.5 -$2.3 1.2 1.6
                         
Grand Average   74% 77% $1,081 $145 $955 $73   $2.3 -$40.1 2.8 2.1
Grand Median   76% 47% $246 $47 $180 $1   $1.4 -$25.6 1.6 1.4



originally published 12/05/2003


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