Signals vs Noise Article







October 2003 Stock Report

Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
GENOME THERAPEUTICS CORP $2.92 73% 106% $76 $27 $49 $15 152 $0.3 -$55.6 0.5 2.7
HUMAN GENOME SCIENCES $13.91 78% 42% $1,797 $1,152 $645 $503 1086 $0.6 -$189.2 6.1 1.0
INCYTE CORP $13.14 85% 166% $733 $349 $384 $172 585 $0.7 -$107.2 3.3 1.0
MILLENNIUM PHARMACEUTICALS $15.92 87% 114% $4,755 $1,545 $3,210 $83 2079 $1.5 -$428.0 3.6 1.1
MYRIAD GENETICS $12.66 59% -30% $343 $86 $257 $0 491 $0.5 -$28.4 3.0 1.3
1st Generation Genomics Average   76% 80% $1,541 $632 $909 $155   $0.7 -$161.7 3.3 1.4
1st Generation Genomics Median   78% 106% $733 $349 $384 $83   $0.6 -$107.2 3.3 1.1
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ACLARA BIOSCIENCES $3.50 75% 81% $125 $79 $46 $0 95 $0.5 -$20.4 3.9 0.5
AFFYMETRIX $25.63 86% -2% $1,511 $434 $1,077 $369 877 $1.2 na na 4.2
CALIPER TECHNOLOGIES $5.61 83% 38% $158 $134 $24 $1 251 $0.1 -$38.2 3.5 0.6
CEPHEID $5.26 80% 6% $171 $11 $160 $0 148 $1.1 -$17.7 0.6 1.9
CIPHERGEN BIOSYSTEMS $10.91 78% 272% $314 $21 $294 $30 323 $0.9 -$62.4 0.3 1.8
COMBIMATRIX $4.84 95% na $125 $43 $82 $0 14 na -$26.7 na na
COMPUGEN $4.67 74% 168% $123 na na $0 176 na -$12.8 na na
ILLUMINA $6.05 88% 48% $198 $55 $143 $25 233 $0.6 -$22.0 2.5 3.1
NANOGEN $3.33 67% 72% $74 $30 $44 $0 195 $0.2 -$27.6 1.1 0.4
ORCHID BIOSCIENCES $1.38 69% 165% $88 $4 na $2 492 na -$40.8 na 0.3
SEQUENOM $3.20 76% 37% $128 $75 $53 $10 216 $0.2 -$37.4 2.0 0.3
TRANSGENOMIC $2.10 50% -19% $49 $3 $47 $1 326 $0.1 -$14.4 0.2 0.4
Genomic Supply Average   77% 79% $255 $81 $197 $37   $0.6 -$29.1 1.8 1.4
Genomic Supply Median   77% 48% $127 $43 $68 $1   $0.5 -$26.7 1.5 0.6
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
APPLIED MOLECULAR EVOLUTION $12.42 99% 331% $259 $53 $206 $10 106 $1.9 -$22.8 2.3 1.6
ARENA PHARMACEUTICALS $7.16 84% -1% $205 $163 $42 $0 336 $0.1 -$46.8 3.5 0.7
CELERA GENOMICS GROUP $13.37 93% 62% $969 na na $0 na na na na na
CURAGEN CORP $6.08 86% 60% $301 $372 -$70 $150 857 -$0.1 -$93.7 4.0 0.6
DECODE GENETICS $6.96 89% 245% $373 $69 $303 $46 530 $0.6 -$40.0 1.7 0.9
EXELIXIS $7.43 76% 50% $529 $260 $268 $60 550 $0.5 -$93.6 2.8 1.1
GENAISSANCE PHARMACEUTICALS $2.95 94% 409% $68 $26 $42 $0 104 $0.4 -$15.2 1.7 0.3
GENE LOGIC $4.97 58% -34% $155 $153 $1 $1 264 $0.0 -$15.6 9.8 0.4
GENENCOR INTERNATIONAL $15.30 87% 39% $902 $144 $758 $57 1098 $0.7 na na 1.7
LARGE SCALE BIOLOGY $1.65 89% 27% $43 $11 $31 $0 114 $0.3 -$30.5 0.4 0.2
LEXICON GENETICS $5.60 75% 21% $350 $142 $208 $4 579 $0.4 -$68.6 2.1 1.1
LYNX THERAPEUTICS $5.20 62% 38% $24 $5 $20 $1 128 $0.2 -$11.2 0.4 0.2
MAXYGEN $9.50 61% 26% $331 $192 $138 $0 280 $0.5 -$22.4 8.6 0.8
NUVELO $3.41 85% 154% $218 $25 $192 $5 98 $2.0 -$64.0 0.4 1.1
PARADIGM GENETICS $1.17 60% 56% $38 $7 $31 $2 194 $0.2 -$14.4 0.5 0.4
RIGEL PHARMACEUTICALS $13.32 87% -1% $197 $12 $185 $0 160 $1.2 -$42.0 0.3 1.4
SANGAMO BIOSCIENCES $4.96 89% 144% $123 $46 $77 $0 74 $1.0 -$13.2 3.5 1.0
ZYMOGENETICS $12.31 68% 42% $569 $329 $240 $0 364 $0.7 -$52.5 6.3 1.3
Genomic Targets Average   80% 93% $314 $118 $157 $19   $0.6 -$40.4 3.0 0.9
Genomic Targets Median   86% 46% $238 $69 $138 $1   $0.5 -$35.3 2.2 0.9
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
EDEN BIOSCIENCES $1.49 66% -10% $36 $23 $13 $0 55 $0.2 -$13.2 1.7 0.3
EMBREX $10.24 76% -9% $84 $10 $74 $0 241 $0.3 na na 1.3
IDEXX LABORATORIES $47.30 97% 37% $1,639 $192 $1,447 $0 1281 $1.1 na na 4.6
IMMUCELL CORP $3.13 64% 66% $9 $4 $4 $0 26 $0.2 na na 0.9
NEOGEN $20.05 98% 56% $126 $8 $118 $0 265 $0.4 na na 5.0
Agbio/enviro. Average   80% 28% $379 $47 $331 $0   $0.5 -$13.2 1.7 2.4
Agbio/enviro. Median   76% 37% $84 $10 $74 $0   $0.3 -$13.2 1.7 1.3
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ALEXION PHARMACEUTICALS $18.50 85% 82% $337 $279 $58 $124 172 $0.3 -$85.9 3.2 0.9
ATHEROGENICS $16.52 88% 150% $603 $61 $543 $100 85 $6.4 -$49.2 1.2 3.5
AUTOIMMUNE $1.60 71% 86% $27 $11 $16 $0 2 $8.0 -$0.6 19.4 0.2
CONNETICS CORP $17.91 92% 40% $568 $27 $540 $80 190 $2.8 -$7.2 3.8 3.3
CORTECH $2.65 81% 0% $10 $0 $10 $0 na na -$0.3 -0.2 na
CYPRESS BIOSCIENCE $13.22 100% 958% $248 $3 $245 $0 10 $24.5 -$30.0 0.1 2.1
ICOS CORP $46.72 98% 89% $2,923 $117 $2,806 $250 525 $5.3 -$156.0 0.7 3.7
INKINE PHARMACEUTICAL CO $5.35 92% 331% $250 $12 $238 $12 49 $4.9 na na 3.9
LA JOLLA PHARMACEUTICAL CO $3.41 38% -38% $145 $51 $95 $1 156 $0.6 -$39.7 1.3 0.7
PROTEIN DESIGN LABS $13.48 66% 62% $1,263 $587 $675 $400 397 $1.7 -$20.0 29.4 2.0
TANOX $17.86 78% 85% $792 $216 $576 $5 127 $4.5 na na 2.6
Autoimmune Average   81% 168% $651 $124 $528 $88   $5.9 -$43.2 6.6 2.3
Autoimmune Median   85% 85% $337 $51 $245 $12   $4.7 -$30.0 1.3 2.3
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ALLOS THERAPEUTICS $2.98 36% -58% $77 $37 $40 $0 92 $0.4 -$46.8 0.8 0.5
ANTIGENICS $10.94 68% 16% $432 $86 $345 $0 212 $1.6 -$66.4 1.3 1.2
APHTON CORP $6.88 69% 244% $170 $2 $168 $3 56 $3.0 -$32.6 na 1.3
ARIAD PHARMACEUTICALS $7.09 95% 204% $276 $17 $259 $6 52 $5.0 -$17.6 1.0 1.7
AVI BIOPHARMA $4.85 65% -6% $151 $8 $143 $0 89 $1.6 -$14.0 0.6 1.1
BIOMIRA $1.71 35% 43% $109 $78 $30 $0 115 $0.3 -$17.8 4.4 1.2
BOSTON LIFE SCIENCES $1.67 56% 42% $54 $11 $43 $0 14 $3.1 -$7.6 1.5 na
CELGENE CORP $41.69 85% 88% $3,378 $258 $3,120 $400 560 $5.6 na na 5.6
CELL THERAPEUTICS $10.40 66% 68% $347 $79 $268 $190 286 $0.9 -$122.8 0.6 0.9
CORIXA CORP $6.01 61% -30% $330 $41 $289 $106 366 $0.8 -$83.6 0.5 0.3
CYTOGEN CORP $11.00 74% 184% $121 $9 $112 $0 49 $2.3 -$7.8 1.2 0.3
DENDREON $8.42 80% 149% $370 $39 $331 $0 117 $2.8 -$33.2 1.2 2.3
DUSA PHARMACEUTICALS $5.31 78% 259% $74 $44 $30 $1 43 $0.7 -$15.2 2.9 0.8
ENTREMED $4.94 76% 198% $156 $1 $155 $0 58 $2.7 -$22.0 0.0 0.7
EXEGENICS $0.52 58% -20% $8 na na $0 8 na -$7.2 na 0.1
GENAERA $4.10 63% 979% $149 $6 $142 $0 22 $6.5 -$6.1 1.0 0.8
GENTA $10.70 61% 37% $802 $100 $702 $28 96 $7.3 -$12.6 8.0 2.5
GERON CORP $12.66 75% 217% $420 $90 $329 $16 92 $3.6 -$36.8 2.5 1.6
ILEX ONCOLOGY $20.86 96% 240% $813 $246 $567 $37 277 $2.0 -$35.2 7.0 1.8
IMCLONE SYSTEMS $34.75 71% 385% $2,592 $259 $2,333 $242 399 $5.8 -$138.0 1.9 7.5
IMMUNOGEN $8.50 88% 165% $424 $508 -$84 $0 1618 -$0.1 -$27.6 18.4 0.2
IMMUNOMEDICS $5.28 81% -24% $381 $25 $356 $0 94 $3.8 -$14.8 1.7 2.4
MAXIM PHARMACEUTICALS $6.00 81% 99% $140 $76 $64 $1 115 $0.6 -$49.6 1.5 0.4
MEDAREX $7.15 93% 80% $554 $292 $262 $175 431 $0.6 -$116.5 2.5 0.9
NAPRO BIOTHERAPEUTICS $1.77 56% -4% $54 $4 $50 $25 151 $0.3 -$8.5 0.5 0.5
NEOPHARM $15.28 82% -1% $288 $64 $224 $0 100 $2.2 -$65.6 1.0 1.7
NEORX CORP $5.28 74% 711% $144 $17 $127 $5 36 $3.5 na na 0.6
OSI PHARMACEUTICALS $28.00 73% 62% $1,013 $279 $734 $295 429 $1.7 -$300.0 0.9 1.4
OXIGENE $10.21 53% 796% $145 $9 $137 $0 10 $13.7 -$5.9 1.4 1.7
PRAECIS PHARMACEUTICALS $6.93 96% 155% $360 $166 $194 $33 110 $1.8 -$62.0 2.7 1.0
PROGENICS PHARMACEUTICALS $17.81 85% 149% $230 $25 $205 $0 100 $2.1 -$31.2 0.8 2.5
QLT INC $15.45 85% 88% $1,062 $137 $925 $172 336 $2.8 na na 2.7
SCICLONE PHARMACEUTICALS $7.98 82% 107% $354 $66 $288 $6 97 $3.0 -$11.4 5.8 2.2
SEATTLE GENETICS $5.90 84% 107% $182 $16 $166 $0 97 $1.7 -$22.0 0.7 1.7
SPECTRUM PHARMACEUTICALS $7.22 70% 241% $30 $3 $27 $0 18 $1.5 -$6.6 0.4 0.2
SUPERGEN $10.32 94% 281% $364 $19 $345 $8 107 $3.2 -$50.0 0.4 1.3
VERNALIS $2.56 71% 12% $44 $269 -$226 $5 96 -$2.4 -$59.4 4.5 0.1
XENOVA GROUP PLC $2.40 33% -48% $41 $29 $12 $0 134 $0.1 -$23.6 1.2 1.4
Cancer Average   72% 163% $438 $92 $357 $46   $2.6 -$45.1 2.4 1.5
Cancer Median   74% 103% $253 $41 $194 $1   $2.1 -$27.6 1.2 1.2
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
CV THERAPEUTICS $17.70 43% -26% $503 $378 $125 $196 205 $0.6 -$91.4 4.1 0.9
ENCYSIVE PHARMACEUTICALS $6.33 88% 233% $281 $34 $248 $0 104 $2.4 -$56.8 0.6 1.3
MEDICINES COMPANY $26.65 85% 84% $1,255 $136 $1,119 $0 147 $7.6 -$26.3 5.2 2.8
QUESTCOR PHARMACEUTICALS $0.77 57% -27% $34 $13 $21 $3 52 $0.4 -$8.4 1.5 0.4
Cardiovascular Average   68% 66% $519 $140 $378 $50   $2.8 -$45.7 2.9 1.4
Cardiovascular Median   71% 29% $392 $85 $186 $2   $1.5 -$41.6 2.8 1.1
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ALBANY MOLECULAR RESEARCH $14.70 81% -5% $467 $132 $336 $66 860 $0.4 na na 2.6
ARGONAUT TECHNOLOGIES $1.20 69% 35% $24 $22 $3 $12 215 $0.0 -$7.6 2.8 0.2
ARQULE $5.20 80% -9% $122 $84 $38 $5 298 $0.1 na na 0.5
ARRAY BIOPHARMA $5.75 63% -31% $163 $35 $127 $0 245 $0.5 -$23.6 1.5 1.3
BIOCRYST PHARMACEUTICALS $8.08 86% 808% $143 $20 $123 $0 44 $2.8 -$13.0 1.5 1.1
DISCOVERY PARTNERS $5.70 88% 111% $140 $69 $71 $0 236 $0.3 -$5.2 13.3 0.7
KOSAN BIOSCIENCES $9.42 96% 53% $241 $53 $188 $0 112 $1.7 -$2.1 25.5 1.7
PHARMACOPEIA $12.44 77% 27% $296 $143 $153 $0 687 $0.2 -$14.8 9.6 1.0
SYMYX TECHNOLOGIES $21.15 83% 84% $662 $128 $535 $0 213 $2.5 na na 4.3
VERTEX PHARMACEUTICALS $13.12 61% -33% $1,010 $639 $371 $315 980 $0.4 -$164.0 3.9 1.3
Chemistry Average   78% 104% $327 $132 $194 $40   $0.9 -$32.9 8.3 1.5
Chemistry Median   81% 31% $202 $77 $140 $0   $0.4 -$13.0 3.9 1.2
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ADOLOR $18.28 90% 33% $579 $123 $456 $0 124 $3.7 -$55.2 2.2 2.2
CEPHALON $47.07 80% -6% $2,614 $565 $2,049 $1,610 1271 $1.6 na na 2.5
DOV PHARMACEUTICALS $12.25 65% 163% $200 $53 $148 $14 32 $4.6 -$18.8 2.8 2.4
GUILFORD PHARMACEUTICALS $7.32 89% 46% $212 $61 $151 $64 235 $0.6 -$22.1 2.7 0.6
INDEVUS PHARMACEUTICALS $5.47 79% 172% $257 $21 $236 $72 24 $9.8 -$48.2 0.4 0.8
NEUROBIOLOGICAL TECHNOLOGIES $5.19 59% 49% $100 $4 $96 $0 11 $8.7 -$2.8 1.4 2.2
NEUROCRINE BIOSCIENCES $46.88 78% 4% $1,475 $496 $979 $0 276 $3.5 -$41.2 12.0 3.4
NYMOX PHARMACEUTICAL $2.49 55% -29% $59 na na $0 228 na -$4.5 na na
PAIN THERAPEUTICS $6.30 70% 62% $174 $95 $79 $0 30 $2.6 -$23.9 4.0 1.7
PHARMOS CORP $3.90 78% 268% $277 $12 $265 $42 67 $4.0 -$17.2 0.7 2.3
STEMCELLS $1.74 61% 216% $59 $2 $57 $0 28 $2.0 -$10.4 0.2 0.4
TITAN PHARMACEUTICALS $3.29 82% 46% $91 $59 $32 $0 72 $0.4 -$26.7 2.2 0.5
CNS Average   74% 85% $508 $135 $413 $150   $3.8 -$24.6 2.9 1.7
CNS Median   78% 47% $206 $59 $151 $0   $3.5 -$22.1 2.2 2.2
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
BIOSOURCE INTERNATIONAL $7.18 90% 19% $66 $4 $62 $0 296 $0.2 na na 1.5
GTC BIOTHERAPEUTICS $3.29 76% 186% $93 $42 $51 $13 182 $0.3 -$24.0 1.7 0.5
HARVARD BIOSCIENCE $7.47 85% 149% $225 $10 $215 $0 386 $0.6 na na 1.3
ICON PLC $42.71 95% 77% $506 $54 na $0 1637 na na na na
INVITROGEN CORP $63.59 98% 128% $3,196 $781 $2,415 $697 2744 $0.9 na na 1.7
MOLECULAR DEVICES CORP $17.76 86% 32% $265 $58 $208 $0 433 $0.5 na na 1.4
NEOSE TECHNOLOGIES $8.16 58% 11% $141 $42 $99 $8 124 $0.8 -$39.7 1.1 0.7
PARAXEL INTERNATIONAL $16.72 94% 39% $432 $79 $353 $1 4930 $0.1 na na 2.5
PHARMACEUTICAL PRODUCT DEVELOP $30.19 94% 10% $1,688 $203 $1,485 $6 5300 $0.3 na na 6.2
QIAGEN NV $11.74 89% 75% $1,710 $41 $1,669 $0 1651 $1.0 na na 34.5
CRO/Service/Supply Average   86% 73% $832 $131 $729 $73   $0.5 -$31.8 1.4 5.6
CRO/Service/Supply Median   89% 57% $349 $48 $215 $0   $0.5 -$31.8 1.4 1.5
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ABGENIX $12.25 72% 80% $1,078 $280 $798 $200 387 $2.1 -$264.4 1.1 1.1
AEROGEN $2.80 44% -14% $11 $1 $11 $0 80 $0.1 -$14.6 0.1 0.1
ALKERMES $12.97 80% 41% $1,158 $128 $1,030 $385 520 $2.0 -$120.0 1.1 2.4
ANDRX $19.83 77% 28% $1,427 $81 $1,346 $0 2100 $0.6 na na 2.9
ARADIGM CORP $2.13 61% -24% $116 $29 $87 $0 285 $0.3 -$29.6 1.0 0.4
ATRIX LABORATORIES $20.09 65% 10% $421 $95 $326 $0 167 $2.0 -$2.9 33.0 1.6
BIODELIVERY SCIENCES $2.60 52% -4% $18 $5 $13 $0 19 $0.7 -$1.2 4.4 1.3
CIMA LABS $31.40 98% 34% $455 $75 $380 $0 219 $1.7 na na 1.9
DEPOMED $6.25 74% 268% $161 $46 $115 $0 51 $2.3 -$28.8 1.6 2.3
DOR  BIOPHARMA $0.66 39% 164% $18 $2 $16 $0 5 $3.2 -$3.2 0.7 0.2
DURECT $2.23 50% -31% $113 $32 $81 $50 6 $13.4 -$20.5 1.6 0.6
EMISPHERE TECHNOLOGIES $6.25 68% 61% $113 $41 $72 $34 124 $0.6 -$45.8 0.9 0.4
ENZON PHARMACEUTICALS $11.16 53% -42% $486 $140 $346 $0 127 $2.7 na na 1.8
FLAMEL TECHNOLOGIES SA $25.25 58% 822% $412 $77 $335 $2 150 $2.2 -$8.9 8.7 8.1
GENEREX BIOTECHNOLOGY $1.75 60% -10% $48 $8 $40 $2 23 $1.7 -$12.6 0.7 0.5
GENETRONICS BIOMEDICAL LTD $1.01 70% 237% $52 $1 $51 $0 26 $2.0 -$5.6 0.1 0.9
KOS PHARMACEUTICALS $39.96 93% 163% $858 $38 $820 $0 726 $1.1 na na 3.9
MACROCHEM CORP $1.14 69% 34% $32 $7 $25 $0 13 $1.9 -$2.2 3.2 0.4
MEDICIS PHARMACEUTICAL $63.35 99% 38% $1,738 $552 $1,185 $400 279 $4.2 na na 3.9
NASTECH PHARMACEUTICAL $9.10 76% -14% $94 $14 $80 $4 63 $1.3 -$11.7 1.2 1.5
NEKTAR THERAPEUTICS $13.14 85% 107% $733 $239 $495 $399 680 $0.7 -$52.0 4.6 1.0
NOVAVAX $6.81 79% 72% $205 $9 $196 $41 121 $1.6 -$20.0 0.5 1.7
NOVEN PHARMACEUTICALS $10.10 67% -21% $227 $68 $159 $0 274 $0.6 na na 2.9
SEPRACOR $26.62 81% 206% $2,255 $448 $1,807 $983 818 $2.2 -$135.2 3.3 2.9
Delivery Average   70% 92% $510 $101 $409 $104   $2.1 -$43.3 3.8 1.9
Delivery Median   69% 36% $216 $44 $177 $0   $1.8 -$17.3 1.1 1.6
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
ADVANCED MAGNETICS $9.02 66% 117% $70 $16 $54 $0 23 $2.3 na na 1.6
BIOSITE $25.80 45% -11% $399 $79 $321 $7 513 $0.6 na na 4.9
CHOLESTECH CORP $7.32 57% 24% $101 $17 $84 $0 220 $0.4 na na 1.2
DIAGNOSTIC PRODUCTS CORP $40.82 92% -1% $1,174 $49 $1,124 $0 2100 $0.5 na na 19.1
DIGENE CORP $35.10 71% 323% $651 $31 $620 $3 243 $2.6 na na 5.6
ENZO BIOCHEM $18.50 65% 27% $555 $77 $479 $0 231 $2.1 -$10.1 7.6 3.5
EPIX MEDICAL $18.51 90% 191% $408 $18 $390 $0 93 $4.2 -$13.6 1.3 3.4
EXACT SCIENCES $10.62 59% -28% $203 $27 $176 $0 75 $2.3 -$31.5 0.9 1.7
GEN-PROBE $26.77 78% 159% $1,278 $8 na $0 186 na na na na
HYCOR BIOMEDICAL $5.00 77% 181% $40 $5 $35 $0 148 $0.2 na na 3.1
IGEN INTERNATIONAL $57.95 96% 62% $1,379 $34 $1,344 $45 370 $3.6 -$28.8 1.2 5.7
IMMUCOR $2.23 57% -90% $72 $9 $63 $20 481 $0.1 na na 2.4
LUMINEX $8.77 91% 35% $260 $38 $223 $0 117 $1.9 -$7.6 4.9 2.1
MARTEK BIOSCIENCES CORP $48.41 83% 208% $1,334 $196 $1,137 $0 198 $5.7 na na 4.1
MATRITECH $1.75 58% -9% $56 $5 $51 $4 50 $1.0 -$7.2 0.7 0.7
MERIDIAN BIOSCIENCE $9.96 87% 73% $147 $5 $141 $23 350 $0.4 na na 6.1
ORASURE $8.41 77% 66% $324 $15 $309 $3 187 $1.7 na na 2.1
QUIDEL CORP $9.10 98% 192% $265 $13 $252 $10 330 $0.8 -$1.5 8.9 1.9
SONUS PHARMACEUTICALS $5.76 89% 287% $102 $11 $91 $0 37 $2.5 -$12.4 0.9 1.8
TRINITY BIOTECH PLC $3.79 86% 232% $163 $1 $161 $0 332 $0.5 na na 7.5
Diagnostic/imag. Average   76% 102% $449 $33 $371 $6   $1.8 -$14.1 3.3 4.1
Diagnostic/imag. Median   77% 69% $263 $17 $223 $0   $1.7 -$11.2 1.2 3.1
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
AASTROM BIOSCIENCES $1.26 69% 448% $90 $7 $82 $0 44 $1.9 -$11.2 0.7 0.8
AVIGEN $7.00 68% 17% $141 $98 $42 $8 102 $0.4 -$24.2 4.1 0.6
CELL GENESYS $12.83 84% 23% $504 $142 $362 $60 336 $1.1 -$76.0 1.9 1.7
CORAUTUS GENETICS $4.39 68% 28% $44 $0 $44 $0 17 $2.6 -$11.6 0.0 0.7
GENVEC $3.40 77% 31% $78 $6 $72 $6 95 $0.8 -$24.0 0.2 0.7
INTROGEN $8.24 73% 302% $195 $15 $180 $7 50 $3.6 -$16.2 0.9 2.1
SIRNA THERAPEUTICS $7.83 68% 253% $247 $37 $210 $4 81 $2.6 -$31.2 1.2 1.2
TARGETED GENETICS CORP $2.53 57% 172% $148 $12 $136 $0 125 $1.1 -$3.1 3.9 0.7
TRANSGENE SA $2.39 51% 108% $72 $0 $72 $0 318 $0.2 -$20.4 0.0 na
TRANSKARYOTIC THERAPIES $13.12 85% 13% $461 $191 $269 $0 345 $0.8 -$84.0 2.3 0.7
VALENTIS $3.20 34% -59% $18 $4 $14 $0 58 $0.2 -$8.2 0.5 0.1
VICAL $5.94 76% 75% $119 $95 $25 $0 165 $0.1 -$27.6 3.4 0.6
Gene therapy Average   68% 117% $176 $51 $126 $7   $1.3 -$28.1 1.6 0.9
Gene therapy Median   69% 53% $130 $14 $77 $0   $0.9 -$22.2 1.1 0.7
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
AVANT IMMUNOTHERAPEUTICS $2.31 67% 65% $150 $17 $133 $0 66 $2.0 -$12.8 1.3 0.7
CUBIST PHARMACEUTICALS $11.55 78% 79% $352 $89 $263 $208 204 $1.3 -$100.0 0.9 1.4
EPIMMUNE $2.28 53% 53% $28 $6 $22 $0 52 $0.4 -$8.1 0.7 0.2
GENELABS TECHNOLOGIES $1.68 75% 28% $106 $28 $78 $0 94 $0.8 -$16.8 1.7 0.6
IMMUNE RESPONSE CORP $4.65 77% 191% $196 na na $5 43 na -$37.2 na 0.8
INTERMUNE $20.03 53% -45% $637 $257 $380 $150 250 $1.5 -$81.2 3.2 1.3
INTRABIOTICS $13.55 87% 214% $44 $8 $37 $0 8 $4.6 -$15.2 0.5 0.2
MEDIMMUNE $26.66 63% 4% $6,661 $581 $6,080 $717 1505 $4.0 na na 2.5
NABI BIOPHARMACEUTICALS $11.04 91% 86% $522 $47 $475 $0 722 $0.7 na na 3.2
SIGA TECHNOLOGIES $2.58 92% 158% $44 $0 $44 $0 17 $2.6 -$4.8 0.1 1.4
TRIMERIS $25.60 45% -52% $551 $122 $429 $0 129 $3.3 -$72.0 1.7 1.4
VAXGEN $9.43 41% -37% $193 $3 $191 $0 117 $1.6 -$30.1 0.1 1.2
VICURON $18.34 97% 67% $987 $203 $785 $0 28 $28.0 -$103.2 2.0 2.2
VION PHARMACEUTICALS $1.79 60% 588% $59 $5 $54 $0 34 $1.6 -$12.5 0.4 0.5
VIROLOGIC $1.68 75% 47% $55 $7 $48 $0 170 $0.3 -$10.8 0.7 0.4
VIROPHARMA $3.06 64% 244% $79 $137 -$58 $130 139 -$0.4 -$28.9 4.7 0.3
XOMA LTD $7.49 70% 30% $544 $89 $455 $71 229 $2.0 -$64.0 1.4 1.0
Infection Average   70% 101% $659 $100 $588 $75   $3.4 -$39.8 1.4 1.1
Infection Median   70% 65% $193 $38 $162 $0   $1.6 -$28.9 1.1 1.0
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
AMYLIN PHARMACEUTICALS $27.33 89% 57% $2,547 $418 $2,130 $175 350 $6.1 -$148.0 2.8 3.7
BIOMARIN PHARMACEUTICAL $7.00 51% 9% $446 $155 $291 $125 219 $1.3 -$39.6 3.9 1.1
INSMED INC $3.08 82% 555% $118 $19 $99 $0 23 $4.3 -$13.0 1.4 na
KERYX BIOPHARMACEUTICALS $5.02 87% 329% $106 $21 $85 $0 24 $3.5 -$6.0 3.4 1.5
NPS PHARMACEUTICALS $26.33 79% 1% $968 $145 $823 $170 183 $4.5 -$256.0 0.6 2.0
SAVIENT PHARMACEUTICALS $6.00 89% 89% $356 $26 $330 $11 490 $0.7 na na 1.7
VIVUS $3.73 63% 14% $140 $20 $120 $0 119 $1.0 -$11.7 1.7 1.0
ZONAGEN $1.85 94% 48% $21 $24 -$3 $0 4 -$0.6 -$2.7 8.8 0.2
Metabolic Average   79% 138% $588 $103 $485 $60   $2.6 -$68.1 3.2 1.6
Metabolic Median   87% 57% $140 $24 $120 $1   $1.3 -$12.3 2.3 1.3
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
BIOPURE CORP $3.46 38% -33% $154 $4 $150 $10 249 $0.6 -$45.2 0.1 0.4
BIORELIANCE CORP $34.18 95% 25% $285 $39 $246 $10 638 $0.4 na na 5.0
BIOTIME $1.67 56% 59% $23 $0 $23 $2 12 $1.9 -$3.0 0.0 0.7
CERUS $4.49 18% -75% $99 $134 -$35 $51 158 -$0.2 -$66.8 2.0 2.5
COLLAGENEX PHARMACEUTICALS $9.62 57% 37% $111 $11 $99 $0 148 $0.7 na na 1.3
COLUMBIA LABORATORIES $10.58 66% 182% $416 $2 $413 $10 25 $16.5 -$18.0 0.1 3.3
CURIS $4.85 87% 736% $181 $31 $150 $7 64 $2.3 -$20.2 1.6 0.3
CYANOTECH CORP $0.57 76% 4% $10 $0 $10 $4 58 $0.2 -$0.6 0.9 0.4
CYTRX CORP $2.21 59% 602% $63 $1 $63 $0 3 $20.8 -$20.2 0.0 0.8
DISCOVERY LABORATORIES $7.24 85% 258% $299 $9 $289 $0 65 $4.5 -$19.2 0.5 3.4
INSITE VISION $0.38 38% -58% $10 $0 $10 $0 41 $0.2 -$7.6 0.0 0.1
INSPIRE PHARMACEUTICALS $18.62 87% 221% $591 $99 $492 $0 54 $9.1 -$26.4 3.8 3.0
INTEGRA LIFESCIENCES $33.74 100% 144% $901 $135 $767 $105 760 $1.0 na na 3.0
NORTHFIELD LABORATORIES $6.02 61% 15% $97 $9 $88 $0 60 $1.5 -$11.6 0.8 0.8
OSTEOTECH $8.09 50% 46% $138 $17 $121 $15 338 $0.4 na na 2.2
PALATIN TECHNOLOGIES $4.30 73% 207% $186 $19 $167 $0 46 $3.6 -$25.6 0.7 1.7
PHARMACYCLICS $5.64 90% 119% $92 $87 $5 $0 133 $0.0 -$30.1 2.9 0.3
REPLIGEN CORP $5.09 60% 57% $152 $15 $137 $0 39 $3.5 -$8.1 1.9 0.9
SALIX PHARMACEUTICALS $19.64 98% 140% $424 $33 $391 $0 135 $2.9 -$28.0 1.2 3.2
TRIPOS $7.00 71% -26% $63 $11 $52 $4 337 $0.2 na na 1.7
Other Average   68% 133% $215 $33 $182 $11   $3.5 -$22.0 1.1 1.8
Other Median   71% 59% $138 $11 $121 $1   $1.0 -$19.7 0.8 1.3
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
AMGEN $61.76 85% 33% $79,670 $5,369 $74,301 $3,056 10100 $7.4 na na 4.1
BIOGEN $40.42 80% 10% $6,043 $868 $5,175 $37 2633 $2.0 na na 7.3
CHIRON CORP $54.63 96% 38% $10,190 $905 $9,286 $564 4044 $2.3 na na 4.2
GENENTECH $81.97 93% 140% $42,448 $1,217 $41,231 $0 5252 $7.9 na na 6.4
GENZYME CORP $45.90 88% 65% $10,193 $546 $9,646 $600 5600 $1.7 na na 3.6
GILEAD SCIENCES $54.55 77% 57% $10,984 $712 $10,272 $595 1250 $8.2 na na 10.8
IDEC PHARMACEUTICALS CORP $35.14 74% -24% $5,463 $905 $4,558 $871 995 $4.6 na na 5.5
Revenue-driven Average   85% 46% $23,570 $1,503 $22,067 $818   $4.9 na na 6.0
Revenue-driven Median   85% 38% $10,193 $905 $9,646 $595   $4.6 na na 5.5
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
DIVERSA $8.43 70% -13% $361 $142 $219 $11 279 $0.8 -$50.4 2.8 1.1
DYAX $4.95 66% 278% $122 $25 $97 $18 244 $0.4 -$24.4 1.0 0.8
ISIS PHARMACEUTICALS $6.65 62% -32% $369 $246 $123 $200 523 $0.2 -$93.2 2.6 0.6
LIGAND PHARMACEUTICALS $13.78 83% 109% $956 $22 $934 $159 402 $2.3 -$48.0 0.5 1.4
NEUROGEN CORP $5.50 71% -17% $99 $63 $35 $14 163 $0.2 -$31.2 2.0 0.6
ONYX PHARMACEUTICALS $24.42 91% 548% $711 $102 $609 $0 89 $6.8 -$45.6 2.2 3.6
REGENERON PHARMACEUTICALS $13.84 61% -9% $721 $283 $438 $200 266 $1.6 -$114.8 2.5 1.2
TULARIK $12.57 95% 73% $746 $156 $590 $0 430 $1.4 -$103.6 1.5 1.8
Screening Average   75% 117% $511 $130 $381 $75   $1.7 -$63.9 1.9 1.4
Screening Median   71% 32% $540 $122 $329 $16   $1.1 -$49.2 2.1 1.1
                         
Company Close 10/31/03 % 52wk High % change from 10/31/02 Market Cap ($M) Cash & Mkt. Sec. ($M) Tech Value ($M) LT Debt plus Convert. # of Staff Tech Value/ Staff ($M) Est. Burn Rate ($M) Survival Index (Yrs) Equity Multiple
CARRINGTON LABORATORIES $3.78 59% 320% $38 $2 $36 $2 252 $0.1 -$1.2 1.7 0.7
CELLEGY PHARMACEUTICALS $2.97 49% 34% $59 $7 $52 $0 23 $2.3 -$18.3 0.4 0.6
CURATIVE HEALTH SERVICES $14.35 73% -4% $182 $5 $177 $24 340 $0.5 na na 1.7
LIFECELL CORP $6.10 82% 184% $155 $6 $149 $1 155 $1.0 na na 2.0
LIFECORE BIOMEDICAL $7.13 77% 10% $92 $3 $89 $6 199 $0.4 -$2.3 1.2 1.9
Wound Average   68% 109% $105 $5 $101 $7   $0.9 -$7.3 1.1 1.4
Wound Median   73% 34% $92 $5 $89 $2   $0.5 -$2.3 1.2 1.7
                         
Grand Average   75% 107% $1,098 $139 $978 $73   $2.2 -$40.1 2.8 2.0
Grand Median   76% 61% $239 $44 $181 $1   $1.3 -$25.6 1.6 1.3



originally published 11/11/2003


Copyright © 2012. Signals (signalsmag.com) is an online magazine of analysis for biotechnology executives. To contact the Signals editorial department, send e-mail to signals_edit@deloitte.com. Signals is published by: Recap, 2033 N Main Street, Suite 1050 , Walnut Creek, California 94596-3722, Phone: (925) 952-3870